Johns Hopkins
Engineering Design Day

Tuesday, May 4, 2021

The Johns Hopkins Engineering community is creating a better future, translating theoretical knowledge into real-world solutions.

 

Join us on Tuesday, May 4 for a virtual celebration showcasing student innovation and creativity at Hopkins Engineering annual Design Day!

design projects

engineering students

project directors

Design Day Projects


Deep Learning Guided Design of Peptide Binders

Team: Independent Design: Jody Mou

Program: Biomedical Engineering

The ability to generate proteins with desired properties remains one of the most complex yet impactful problems in biology and medicine. In particular, peptides are small protein fragments that hold significant potential as therapeutics. Peptides have a $25 billion addressable market, and are known to “bridge the pharmaceutical gap” between small molecule drugs and larger biologics such as antibodies. However, many potential drug targets currently have no known peptide binders. This project aims to build a deep generative model that outputs potential peptide binders given the sequence and structure of any receptor protein. We use techniques from deep learning and natural language processing to create a sequence-to-sequence model based on protein primary structure. In addition, the model incorporates structural information from receptors to constrain peptides to a selected binding site. The overall goal of this project is to develop a faster and cheaper computational method for generating early-stage candidates of peptide therapeutics.

Mentors

Team Members

  • Jody Mou

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