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A Novel and Effective Design to Immobilize Enzymes within Protein Crystals

Project Description:

The purpose of this project was to engineer protein crystals as a platform to covalently immobilize enzymes. This project successfully devised a novel strategy to engineer protein crystals in a fashion that could effectively immobilize guest fluorescent proteins (FPs) and selectively immobilize enzymes, such as Candida antarctica lipase B (CALB). While this project focuses on protein crystals in the context of biocatalysis, the applications of protein crystals are far-stretching, including structural characterization and controlled release of drugs via drug delivery.

Project Photo:

A Novel and Effective Design to Immobilize Enzymes within Protein Crystals

A Novel and Effective Design to Immobilize Enzymes within Protein Crystals

Student Team Members

  • Rishi Sheth

Course Faculty

  • Dingchang Lin

Project Mentors, Sponsors, and Partners

  • Dingchang Lin