A Novel and Effective Design to Immobilize Enzymes within Protein Crystals

Program:

Materials Science and Engineering

Project Description:

The purpose of this project was to engineer protein crystals as a platform to covalently immobilize enzymes. This project successfully devised a novel strategy to engineer protein crystals in a fashion that could effectively immobilize guest fluorescent proteins (FPs) and selectively immobilize enzymes, such as Candida antarctica lipase B (CALB). While this project focuses on protein crystals in the context of biocatalysis, the applications of protein crystals are far-stretching, including structural characterization and controlled release of drugs via drug delivery.

Team Members

Project Mentors, Sponsors, and Partners

  • Dingchang Lin

Course Faculty

Project Links

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Project Photo Caption:

A Novel and Effective Design to Immobilize Enzymes within Protein Crystals

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